Following extensive research and development, Biostage has evolved its technology to optimize the interaction of mesenchymal stem cells seeded on a biocompatible scaffold. Preclinical studies suggest that, once implanted, the scaffold seeded with the patient’s own cells signals the stem cell niche to guide the regeneration of a biological structure.

Cellframe technology may enable the first truly personalized approach to organ regeneration.

Cellframe technology employs a multistep process in which the patient’s own stem cells are taken from a simple adipose/fat tissue biopsy, expanded and banked, and then seeded onto a proprietary scaffold that mimics the natural dimensions of the organ being regenerated. After several days in a rotating bioreactor, the stem cell-containing scaffold is ready to be implanted. Cellframe technology is designed to deliver the necessary cues for triggering, guiding and modulating the regenerative process.

 

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Cellframe technology is based on the concept of in situ tissue regeneration using the body’s own biologic resources and reparative capability in combination with tissue-specific biomaterials implanted at the sites of disease or injury.

Cellframe is a newly developed technology that harnesses the full potential of the in vivo microenvironment to achieve complete tissue regeneration.

Biostage is investigating its Cellframe technology to replace diseased sections of the esophagus, trachea and bronchus, possible life-threatening conditions that are underserved by current therapies.